Farnesoid x receptor fxr 翻译

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August undefined, 2024

Web小鼠法尼醇 X 受体 (FXR) ELISA试剂盒(Mouse Farnesoid X Receptor (FXR) ELISA Kit)适用样本类型tissue homogenates and other biological fluids. 欢迎您访问武汉艾美捷科技 … Web所述化合物是核受体法尼醇受体(fxr)的调节剂，可在制备预防和治疗糖尿病、肥胖症、脂肪肝、肝硬化、高血糖、心血管疾病、高甘油三酯血症、高胆固醇血症、肝损伤、转氨酶增高、胆汁阻塞、胆结石、动脉粥样硬化等疾病的药物或保健品中应用。

Farnesoid X receptor: from medicinal chemistry to clinical …

WebThe farnesoid X receptor (FXR) is a nuclear bile acid receptor controlling bile acid, lipid, and glucose homeostasis. FXR negatively regulates hepatic glycolysis and lipogenesis in … WebNov 7, 2014 · Objective The aim of this paper is to review the developments of farnesoid X receptor (FXR) biology, its ligands, and various functions, in particular we discuss the anti-inflammatory and anti-fibrotic role in chronic inflammatory diseases. Introduction FXR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor … laurane oliva

Farnesoid-X Receptor (FXR) - SelfHacked

Web为探究胆酸(Cholic acid, CA)作为饲料添加剂对大口黑鲈(Micropterus salmoides)生长及糖代谢的影响,实验以饲料中添加300 mg/kg胆酸钠(Sodium cholate, CAS)作为胆酸钠组,以不添加胆酸钠作为对照组。在饲养8周后,分析胆酸钠对大口黑鲈生长性能、肠道菌群、糖代谢及与糖代谢相关酶的活性和基因表达的影响。结果 ... Web生理状态下，FGF19遵循昼夜节律，餐后胆汁酸诱导FXR ... 调节因子，如过氧化物酶体增殖物活化受体γ协同刺激因子-1α（peroxisome proliferator-activated receptor ... ，且该作用与胰岛素的活性无关，而是通过有丝分裂原活化蛋白激酶信号通路激活蛋白质翻译机制并 ... WebDec 23, 2013 · The farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is mainly expressed in liver and small intestine, where it plays an important role in bile acid, lipid, and glucose metabolism. The kidney also has a high FXR expression level, with its physiological function unknown. lauranne hintjens

FXR Farnesoid X Receptor - Selleckchem.com

高胆汁酸血症，中文例句，英文例句-词都网

WebNov 19, 2011 · The farnesoid X receptor (FXRα, gene name NR1H4), is one of the 48 ligand-activated nuclear transcription factor proteins that sense the intracellular presence of specific hydrophobic molecules and respond by inducing changes in gene expression [2, 3•].The primary ligands for FXR are bile acids and thus FXR is a major sensor of … Web胆汁酸合成受到核胆汁酸受体法尼酯x受体（fxr）的密切调控，硫酸化黄体酮代谢物可抑制肝脏摄取胆汁酸，并通过抑制fxr依赖性途径减少其排泄。最近的研究表明，包括ICP在内的胆汁淤积性肝病中的瘙痒可能是由磷脂代谢物如溶血磷脂酸引起的。 laurana sothWeb類法尼醇x受體（Farnesoid X receptor）是核受體超家族的一員，它主要表達在腸道系統之中，參與膽汁酸代謝與膽固醇代謝等重要環節。在自然環境中其配體包括初級膽汁酸鵝脫氧膽酸、次級膽酸石膽酸、脫氧膽酸等。而人工合成物6-ECDCA、GW406等的結合性超過了天 … lauranne jansen

"WebFXR is mainly expressed in liver, intestine, kidneys, and adrenal gland, with less expression in adipose tissue and heart ().FXR was originally identified as a receptor for the cholesterol precursor farnesol, but is now recognized as the primary receptor for bile acid (3, 6).The bile acid–FXR interaction plays an integral role in regulating hepatic inflammation and … " - Farnesoid x receptor fxr 翻译

Farnesoid x receptor fxr 翻译

Bioactive compounds from Pu-erh tea with therapy for …

WebMay 9, 2012 · The farnesoid X receptor (FXR) is a bile sensor that acts in coordination with other nuclear receptors to regulate essential steps in bile acid uptake, metabolism and …

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WebMar 21, 2024 · The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific … WebFarnesoid X receptor. Farnesoid X receptor (FXR) is a nuclear hormone receptor with high expression in liver. It regulates many genes involved in lipid and glucose metabolism, liver regeneration, inflammation, and liver cancer (Wang et al., 2008; Modica et al., 2008 ).

Web法尼醇X受体（farnesoid X receptor, FXR），又名胆汁酸受体，属于核受体超家族的一员，是配体激活的转录因子。胆汁酸作为FXR的内源性配体，不仅是脂类消化吸收中的重要物质，还可作为信号分子通过FXR介导 … WebThe farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily. 法尼酯X受体 (farnesoid X receptor,FXR)因其天然配体为胆汁酸,又称为胆汁酸受体,是一种配 …

WebSep 30, 2008 · Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid, cholesterol, lipid ... WebJun 7, 2024 · Prevention of SARS-CoV-2 entry in cells through the modulation of viral host receptors, such as ACE2, could represent a new therapeutic approach complementing vaccination. However, the mechanisms controlling ACE2 expression remain elusive. Here, we identify the farnesoid X receptor (FXR) as a direct regulator of ACE2 transcription in …

WebHere we show that the farnesoid X receptor (FXR) is a direct regulator of ACE2 transcription in several tissues affected by COVID-19, including the gastrointestinal and respiratory systems.

WebNov 3, 2024 · The Farnesoid-X receptor (FXR) also known as bile acid receptor (BAR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4) is a nuclear receptor that is encoded by the NR1H4 gene in humans [ … lauraniiteWeb与对照组比较，模型组的肠FXR蛋白表达明显降低，肠NLRP3蛋白表达明显升高，肠E-cadherin和Occludin表达均明显下降( P 值均＜0.05)；与模型组相比，淤胆通方组和UDCA组的肠FXR表达显著上调，肠NLRP3表达显著下降，肠E-cadherin和Occludin的蛋白表达均显著升高( P 值均＜0.05)。 lauranne issartelWebApr 20, 2024 · Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates … laurann marketosWebDec 23, 2013 · The farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. FXR is mainly expressed in liver and … laurann johnsonWeb说明：双击或选中下面任意单词，将显示该词的音标、读音、翻译等；选中中文或多个词，将显示翻译。 ... The Mechanism of Farnesoid X Receptor and IBABP in Enterohepatic Circulation of Bile Acids of Rats with Intrahepatic Cholestasis of Pregnancy; FXR、IBABP在妊娠肝内胆汁淤积症孕鼠胆汁酸肠 ... lauranne janinWebNHR是一组配体激活的转录因子家族，参与胆汁酸转运和代谢的NHR包括：法尼醇X受体（farnesoid X receptor，FXR）、孕烷X受体（pregnane X receptor，PXR）以及组成型雄烷受体（constitutive androstane receptor，CAR）等。FXR为胆酸感受器，通过调节参与胆酸转运和代谢的基因抑制 ... lauranett leeWebMay 15, 2015 · X marks the spot: 39 trisubstituted isoxazoles were designed and synthesized, leading to compounds with pharmacological profiles ranging from agonist to antagonist at the farnesoid X receptor (FXR). By using the most potent antagonist as a probe, the essential molecular basis of FXR antagonism is proposed, and E467 on H12 … lauranne jaumet