Terpendole

Author: ujwy

August undefined, 2024

Web实验耗材细胞培养皿. 产品型号： ccd06-035 简要描述：实验耗材细胞培养皿金畔生物公司供应：elisa试剂盒,分光光度计，血清，荧光定量pcr耗材，移液器吸嘴，微量离心管，进口冻存管，细胞培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。 WebTerpendole C is an acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. We collect cookies for vital website function and to better serve our customers.

CAS 167612-17-1 Terpendole I - BOC Sciences

WebFeb 8, 2024 · Terpendole E (TerE) is the first natural product that inhibits mitotic kinesin Eg5 (kinesin spindle protein). Recently, TerE is suggested to have a different binding site and/or inhibitory mechanism than other L5 … WebTerpendole E C28H39NO3 CID 10094631 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... chs hermagor

A synthetic approach to terpendoles: …

WebTerpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. … WebDec 15, 2016 · Isolation of a terpendole E analog with stronger kinesin Eg5 inhibitory activity: Overproduction of bioactive compounds may cause production of shunt metabolites with improved bioactivity. Indeed, a new terpendole E analog was isolated from a terP-knockout strain that stably overproduced terpendole E. 11 After prolonged culture, ... WebTerpendole C. Cat. No.: HY-N10224. Data Sheet Handling Instructions. Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase ( ACAT ). For research use only. description of accounting degree

Two New Prenylated Indole Diterpenoids from …

WebFeb 1, 2003 · Terpendole E Is a Selective Inhibitor of Eg5 Rather Than an ACAT Inhibitor. Since terpendole derivatives were isolated as ACAT inhibitors, we next compared the inhibitory activity of TerE with that of other ACAT inhibitors such as terpendole derivatives and FR179254. The results are summarized in Table 1. It has been reported that TerC … WebFeb 1, 2003 · Terpendole E Is a Selective Inhibitor of Eg5 Rather Than an ACAT Inhibitor. Since terpendole derivatives were isolated as ACAT inhibitors, we next compared the … description of a cemetery creative writingWebDec 21, 2012 · Terpendole E is the first natural product inhibitor of kinesin Eg5. Because terpendole E production is unstable, we isolated and analyzed the terpendole E biosynthetic gene cluster, which consists of seven genes encoding three P450 monooxygenases (TerP, TerQ, and TerK), an FAD-dependent monooxygenase (TerM), … description of a charge nurse

"Web16-epi-terpendole E by Giannis and co-workers and a tricyclic right-hand moiety of 1 by the Oikawa group.5,6) We have also addressed the total synthesis of terpendole E, and recently succeeded in a diastereose-lective synthesis of (±)-3 from known Wieland– Miescher ketone analog (±)-2.7,8) In this article, we " - Terpendole

Terpendole

WebThe application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described. WebFirstly, consecutive rings, including an indole or indoline, maintain the cornerstone for SOAT inhibitory activity because the opened ring A leads to the loss of activity in terpendole N. Secondly, the comparison among terpendole D, J, L, O and P; voluhemins A and B; and NK12838 shows that the presence of an isoprenyl-derived moiety at the C-20 ...

Did you know?

WebThe first synthesis of the racemate of terpendole E, a specific inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence … WebRoll is a grey edible mushroom ( Agaricochaete ), containing a variety of vitamins, minerals and different kind of secondary metabolites. Two new terpenoid indole alkaloids (Terpendole N and Terpendole O) were isolated from the fermentation of P. ostreatus. Their structures were elucidated by 1D, 2D NMR, HR-ESI-MS, and ECD. Pleurotus …

http://www.cnreagent.com/s/sv147762.html WebJan 21, 2015 · The challenging molecular architecture of 1 as well as its attractive pharmacological profiles prompted synthetic efforts toward 1, which led to the synthesis of 16-epi-terpendole E by Giannis and co-workers and a tricyclic right-hand moiety of 1 by the Oikawa group. 5,6) We have also addressed the total synthesis of terpendole E, and …

WebJan 2, 2015 · Terpendole E (1), originally isolated from the fungus Albophoma yamanashiensis (syn. Chaunopycnis alba) as a week ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor, 1,) has been gaining increasing attention from cancer researchers since its rediscovery by Osada and co-workers as the first natural inhibitor of the mitotic … WebTerpendole I: ChEBI ID CHEBI:144412: Stars This entity has been manually annotated by a third party. Submitter Mark Williams: Supplier Information Download Molfile XML SDF: …

WebTerpendole I, a fungal indoloditerpene, is a ACAT (acyl-CoA: cholesterol acyltransferase) inhibitor (IC50=145 µM). - Mechanism of Action & Protocol. From 11:00 pm to 12:00 pm …

WebNov 7, 2024 · Diterpenes are one of the classes of natural products with about 7000 structures. The basic skeleton of diterpene contains 20 carbon atoms. Microbes contain … description of a butterflyWebFeb 1, 2024 · Terpendole E is the first natural product inhibitor of kinesin Eg5. Because terpendole E production is unstable, we isolated and analyzed the terpendole E biosynthetic gene cluster, which consists ... chs herman agronomyWebAbstract. Two new prenylated indole diterpenoids, tolypocladins K and L (1 and 2), together with a known analog terpendole L (3), were isolated from the solid fermentation culture … description of a childminderWebJul 6, 2024 · Fraction 60%-2 (249 mg) was subjected to preparative high-performance liquid chromatography (HPLC) to give NK12838 (6) and new terpendole N (1). Purification from fraction 80%-2 (214 mg) by preparative HPLC allowed isolation of three peaks, new terpendole O (2), terpendole C (7) , and a third peak. The third peak was, however, … chs herman grainTerpendole E is the first natural product inhibitor of kinesin Eg5. Because terpendole E production is unstable, we isolated and analyzed the terpendole E biosynthetic gene cluster, which consists of seven genes encoding three P450 monooxygenases (TerP, TerQ, and TerK), an FAD-dependent monooxygenase (TerM), a terpene cyclase (TerB), and two prenyltransferases (TerC and TerF). description of a cherubimWebMar 19, 2014 · Terpendole E is first natural product found to inhibit mitotic kinesin Eg5, but its inhibitory mechanism remains to be revealed. Here, we report the effects of terpendole E and 11ketopaspaline (a new natural terpendole E analogue) on the Eg5–microtubule interaction and in several Eg5 mutants. 11-Ketopaspaline is a shunt product from … description of a characterhttp://www.fluoroprobe.com/archives/tag/ccd chs hershey pa